<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aouachria, Sana</style></author><author><style face="normal" font="default" size="100%">Soumia Mouffok</style></author><author><style face="normal" font="default" size="100%">Souhila Laib</style></author><author><style face="normal" font="default" size="100%">Bensaad, Mohamed Sabri</style></author><author><style face="normal" font="default" size="100%">Boumerfeg, Sabah</style></author><author><style face="normal" font="default" size="100%">Arrar, Lekhmici</style></author><author><style face="normal" font="default" size="100%">Baghiani, Abderrahmane</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Insights into Reichardia picroides L.: Luteolin-7-O-β-Glucoside Isolation, In Silico Analysis, and Bioactivity of Extract and Fractions</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Pharmaceutical Innovation</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2026</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://link.springer.com/article/10.1007/s12247-026-10819-0?utm_source=rct_congratemailt&amp;utm_medium=email&amp;utm_campaign=nonoa_20260704&amp;utm_content=10.1007%2Fs12247-026-10819-0#citeas</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">21</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;font-family:Impact;&quot;&gt;Purpose&lt;/span&gt;&lt;span style=&quot;font-family:Arial,Helvetica,sans-serif;&quot;&gt; &lt;/span&gt;This study investigated the in vitro antioxidant and anti-hemolytic activities of the crude extract (CrE) of Reichardia picroides L. (R. picroides) and its fractions, and aimed to isolate and structurally characterise a bioactive compound supported by computational analysis, including molecular docking on α-glucosidase.
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&lt;p&gt;
	&lt;span style=&quot;font-family:Impact;&quot;&gt;Methods &lt;/span&gt;This study investigated the in vitro antioxidant and anti-hemolytic activities of R. picroides extract and its fractions. A bioactive compound, luteolin-7-O-β-glucoside, was isolated and structurally characterized by NMR spectroscopy. In silico study included molecular docking and ADME evaluation.
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	&lt;span style=&quot;font-family:Impact;&quot;&gt;Results &lt;/span&gt;The ethyl acetate extract (EAE) exhibited the highest phenolic and flavonoid contents and showed pronounced antioxidant and anti-hemolytic activities. EAE significantly prolonged HT₅₀ compared with the control. Molecular docking analysis suggested favorable binding interactions between luteolin-7-O-β-glucoside and α-glucosidase. The DFT and ADME analyses indicated favorable pharmacokinetic properties, although experimental validation is required.
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	&lt;span style=&quot;font-family:Impact;&quot;&gt;Conclusion &lt;/span&gt;The findings provide preliminary evidence that R. picroides contains bioactive constituents with antioxidant and membrane-protective properties. The isolated luteolin-7-O-β-glucoside may contribute to the observed activities. However, further in vivo and mechanistic studies are required to confirm the biological relevance of these effects.
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