@article {6475,
	title = {Composition and biological activity of the Algerian plant Rosa canina L. by HPLC-UV-MS},
	journal = {Arabian Journal of Chemistry},
	volume = {13},
	number = {1},
	year = {2020},
	pages = {1105-1119},
	abstract = {
	The present study was carried out in order to identify and characterize the compounds of\&nbsp;Rosa canina\&nbsp;fruits by HPLC-UV-MS. The total phenolic determiner by a new Fast Blue method (FBBB), which detects phenolic directly, reported an average total phenolic concentration of 1.7 folds greater than Folin-Ciocalteu (F-C), which indicates that an indirect detection method of total phenolic should be replaced in future studies by the FBBB method. TPC of the ethanolic extract was positively correlated with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging effect. The DPPH activity of\&nbsp;R. canina\&nbsp;extract which is higher than the IC50\&nbsp;of the ascorbic acid and Butylated Hydroxytoluene (BHT), but lower than the IC50\&nbsp;of quercetin and trolox. The determination of intracellular reactive oxygen species (ROS) proved the antioxidant effect of the extract on HepG2 and SH-SY5Y cells. A concentration of 1.63 μg/ml on HepG2 cells had an oxidizing effect instead of the antioxidant effect, which is due to the existence of a tert-butyl group in sesquiterpene identified by HPLC-UV-MS method. These results indicate that the fruits of\&nbsp;R. canina\&nbsp;can be used as a natural source of antioxidants against oxidative stress and some types of cancer.



	Ethanolic extract, HPLC-UV-MS,\&nbsp;Antioxidant activity,\&nbsp;Oxidant effect,\&nbsp;Bilobalide A

},
	url = {https://www.sciencedirect.com/science/article/pii/S187853521730182X},
	author = {Samira. Fetni and Nabil Bertella and Ammar Ouahab and Jose Miguel Martinez Zapater and Sonia De Pascual-Teresa Fernandez}
}
