@article {18433,
	title = {The effectiveness of platelet-rich plasma on the skin wound healingprocess: A comparative experimental study in sheep},
	journal = {Veterinary World,},
	volume = {Vol.11},
	number = {2231-0916},
	year = {2018},
	pages = {800-808},
	abstract = {Aim: The therapeutic evaluation of the biological effect of platelet-rich plasma (PRP) used as a surgical adjunct to maintainthe inflammatory process and to potentiate tissue healing, make the subject of recent research in regenerative medicine. Thisstudy was designed to evaluate the healing activity of PRP by its topical application on the skin experimentally injured ina sheep model.Materials and Methods: The study was conducted on 9 adult and clinically healthy males sheep. PRP was obtained by aprotocol of double centrifugation of whole blood from each animal. After sterile skin preparation, full-thickness excisionalwounds (20 mm x 20 mm) were created on the back of each animal. The animals were randomly divided into three equalgroups of three sheep for each. In Group I, the wounds were treated with PRP, in Group II; wounds were treated withAsiaticoside; in Group III, wounds were treated with saline solution. The different treatments were administered topicallyevery 3 days. Morphometric measurements of the contraction surface of the wounds and histopathological biopsies werecarried out at the 3rd, 7th, 14th, 21st, and 28th days of healing.Results: The results of the morphometric data obtained revealed that it was significant differences recorded at the 7th and14th day of healing in favor for animals of Group I. Semi-quantitative histopathological evaluation showed that PRP reducesinflammation during 3 first days post-surgical and promotes epithelialization in 3 weeks of healing.Conclusion: We concluded that topical administration of PRP obtained by double centrifugation protocol could potentiallyimprove the skin healing process in sheep.},
	url = {www.veterinaryworld.org},
	author = {DAIKH Badis and BENOUNE Omar}
}
