@article {73704,
	title = {Histological assessment of topical mixture of Thymus vulgarishoney and Nigella sativa L seed powder on skin wound healingin sheep},
	journal = {international of biosciences },
	volume = {21},
	number = {1},
	year = {2022},
	abstract = {Honey and Nigella sativa L has been known for millennia of years for its therapeutic healing properties. Thispresent histopathological study aims to evaluate the healing activity of Algerian bee honey derived from thenectar of Thymus vulgaris mixed with N. sativa seed powder on a sheep model. Induction of wounds withlongitudinal incisions of full thickness, was carried out in the dorsal part of 09 healthy sheep belonging to theanimal facility of the veterinary department of the University of Batna 1. After inductions of the wounds, theanimals were distributed to the randomly in 03 batches of animals of 03 sheep for each with appropriate topicalcare for each batch: the batch of animals treated with Thymus vulgaris honey mixed with N. sativa seed powder(HNS), the Madicassol batch and the Vaseline. The topical application of the various treatments was carried outonce a day for 02 successive weeks. Histopathological evaluation was performed by measuring scar tissuethickness. In the batch of animals treated with HNS mixture, the thickness of the scar tissues revealed asignificant decrease compared to the Madicassol and Vaseline batches. No keloid or detectable in the wounds ofthe mixture HNS lot. The results of this experimental study suggested that the topical use of local honey from thenectar of T.vulgaris mixed with N. sativa seed powder significantly reduced the thickness of wound healing insheep.},
	author = {deffa ouafa and DAIKH Badis}
}
