<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">deffa ouafa</style></author><author><style face="normal" font="default" size="100%">DAIKH Badis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Histological assessment of topical mixture of Thymus vulgarishoney and Nigella sativa L seed powder on skin wound healingin sheep</style></title><secondary-title><style face="normal" font="default" size="100%">international of biosciences </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year></dates><volume><style face="normal" font="default" size="100%">21</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Honey and Nigella sativa L has been known for millennia of years for its therapeutic healing properties. This&lt;br&gt;present histopathological study aims to evaluate the healing activity of Algerian bee honey derived from the&lt;br&gt;nectar of Thymus vulgaris mixed with N. sativa seed powder on a sheep model. Induction of wounds with&lt;br&gt;longitudinal incisions of full thickness, was carried out in the dorsal part of 09 healthy sheep belonging to the&lt;br&gt;animal facility of the veterinary department of the University of Batna 1. After inductions of the wounds, the&lt;br&gt;animals were distributed to the randomly in 03 batches of animals of 03 sheep for each with appropriate topical&lt;br&gt;care for each batch: the batch of animals treated with Thymus vulgaris honey mixed with N. sativa seed powder&lt;br&gt;(HNS), the Madicassol batch and the Vaseline. The topical application of the various treatments was carried out&lt;br&gt;once a day for 02 successive weeks. Histopathological evaluation was performed by measuring scar tissue&lt;br&gt;thickness. In the batch of animals treated with HNS mixture, the thickness of the scar tissues revealed a&lt;br&gt;significant decrease compared to the Madicassol and Vaseline batches. No keloid or detectable in the wounds of&lt;br&gt;the mixture HNS lot. The results of this experimental study suggested that the topical use of local honey from the&lt;br&gt;nectar of T.vulgaris mixed with N. sativa seed powder significantly reduced the thickness of wound healing in&lt;br&gt;sheep.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DAIKH Badis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative study of the therapeutic efficacy of autologousplatelet-rich plasma and honey in healing skin wounds in sheep</style></title><secondary-title><style face="normal" font="default" size="100%">veterinary wourd</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year></dates><volume><style face="normal" font="default" size="100%">14</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background and Aim: This investigation is the continuation of a published preliminary study examining the therapeutic&lt;br&gt;efficacy of platelet-rich plasma (PRP) as a topical treatment for skin wounds in sheep. The study aimed to compare the&lt;br&gt;healing effects of autologous PRP with that of natural honey.&lt;br&gt;Materials and Methods: This study involved nine clinically healthy male sheep. After sterile skin preparation, fullthickness&lt;br&gt;longitudinal incision wounds were created on the backs of each animal. The animals were randomly divided into&lt;br&gt;three groups of three sheep each. In Group I, the wounds were treated with PRP; in Group II, the wounds were treated with&lt;br&gt;honey; and in Group III, the wounds were treated with saline solution. The different treatments were administered topically&lt;br&gt;every 3 days. Healing was assessed by a semi-quantitative histopathological study from biopsies taken on the 3rd, 7th, 14th,&lt;br&gt;21st, and 28th days of healing. The data obtained were compared using the non-parametric Mann–Whitney U-test, and p&amp;lt;0.05&lt;br&gt;and 0.01 were used to determine the level of significance of the recorded differences.&lt;br&gt;Results: Semi-quantitative histopathological evaluation showed significant differences in the progression of wound healing&lt;br&gt;between the three study groups. Recorded data showed that PRP may reduce inflammation during the first 3 days after the&lt;br&gt;incision. Moreover, the synthesis and organization of collagen fibers were significantly improved in the group treated with&lt;br&gt;PRP compared with those in the group treated with honey.&lt;br&gt;Conclusion: PRP offers a promising therapeutic option for healing skin wounds in sheep compared with honey.&lt;br&gt;Keywords: honey, platelet-rich plasma, sheep, skin, wound healing.</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DAIKH Badis</style></author><author><style face="normal" font="default" size="100%">BENOUNE Omar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">&lt;em&gt;The effectiveness of platelet-rich plasma on the skin wound healingprocess: A comparative experimental study in sheep&lt;/em&gt;</style></title><secondary-title><style face="normal" font="default" size="100%">Veterinary World,</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">www.veterinaryworld.org</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">Vol.11</style></volume><pages><style face="normal" font="default" size="100%">800-808</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Aim: The therapeutic evaluation of the biological effect of platelet-rich plasma (PRP) used as a surgical adjunct to maintain&lt;br&gt;the inflammatory process and to potentiate tissue healing, make the subject of recent research in regenerative medicine. This&lt;br&gt;study was designed to evaluate the healing activity of PRP by its topical application on the skin experimentally injured in&lt;br&gt;a sheep model.&lt;br&gt;Materials and Methods: The study was conducted on 9 adult and clinically healthy males sheep. PRP was obtained by a&lt;br&gt;protocol of double centrifugation of whole blood from each animal. After sterile skin preparation, full-thickness excisional&lt;br&gt;wounds (20 mm x 20 mm) were created on the back of each animal. The animals were randomly divided into three equal&lt;br&gt;groups of three sheep for each. In Group I, the wounds were treated with PRP, in Group II; wounds were treated with&lt;br&gt;Asiaticoside; in Group III, wounds were treated with saline solution. The different treatments were administered topically&lt;br&gt;every 3 days. Morphometric measurements of the contraction surface of the wounds and histopathological biopsies were&lt;br&gt;carried out at the 3rd, 7th, 14th, 21st, and 28th days of healing.&lt;br&gt;Results: The results of the morphometric data obtained revealed that it was significant differences recorded at the 7th and&lt;br&gt;14th day of healing in favor for animals of Group I. Semi-quantitative histopathological evaluation showed that PRP reduces&lt;br&gt;inflammation during 3 first days post-surgical and promotes epithelialization in 3 weeks of healing.&lt;br&gt;Conclusion: We concluded that topical administration of PRP obtained by double centrifugation protocol could potentially&lt;br&gt;improve the skin healing process in sheep.</style></abstract><issue><style face="normal" font="default" size="100%">2231-0916</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DAIKH Badis</style></author><author><style face="normal" font="default" size="100%">BENOUNE Omar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">&lt;em&gt;Comparative Study of Four Methods of Preparationof Autologous Plasma-Rich Platelet in Sheep&lt;/em&gt;</style></title><secondary-title><style face="normal" font="default" size="100%">Global Veterinaria</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.idosi.org/gv/gv.htm</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">559-563</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;b&gt;Abstract: &lt;/b&gt;The therapeutic evaluation of the biological effect of platelet-rich plasma (PRP) is the subject of&lt;br&gt;several studies in regenerative medicine. The aim of this study was to compare four different methods of&lt;br&gt;preparation of autologous platelet concentrates in sheep. Various specimens were collected from six adult&lt;br&gt;healthy male sheep of the local breed. Blood smears were also carried out on all the samples, in order to see the&lt;br&gt;morphology of the platelets. The data obtained in the manual platelet count were submitted to statistical&lt;br&gt;analysis (repeated measures ANOVA, Tukey HSD test, P&amp;lt;0.05). The result was that the total mean number of&lt;br&gt;platelets in whole blood was 521.56 ± 97.01x10 /µl. The PRP samples in Groups I and III showed significantly 3&lt;br&gt;higher mean platelet counts than Group II and IV (1438.25 ± 221.72×10 /µl and 1430.75 ± 293.63×10 /µl, 3 3&lt;br&gt;respectively). In conclusion, within the limit of this study, it can be concluded that the best technique of platelet&lt;br&gt;harvesting in sheep is obtained with the double centrifugation protocol used for animals of group I.&lt;br&gt;&amp;nbsp;</style></abstract><issue><style face="normal" font="default" size="100%">17</style></issue></record></records></xml>