<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DAIKH Badis</style></author><author><style face="normal" font="default" size="100%">BENOUNE Omar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">&lt;em&gt;The effectiveness of platelet-rich plasma on the skin wound healingprocess: A comparative experimental study in sheep&lt;/em&gt;</style></title><secondary-title><style face="normal" font="default" size="100%">Veterinary World,</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">www.veterinaryworld.org</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">Vol.11</style></volume><pages><style face="normal" font="default" size="100%">800-808</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Aim: The therapeutic evaluation of the biological effect of platelet-rich plasma (PRP) used as a surgical adjunct to maintain&lt;br&gt;the inflammatory process and to potentiate tissue healing, make the subject of recent research in regenerative medicine. This&lt;br&gt;study was designed to evaluate the healing activity of PRP by its topical application on the skin experimentally injured in&lt;br&gt;a sheep model.&lt;br&gt;Materials and Methods: The study was conducted on 9 adult and clinically healthy males sheep. PRP was obtained by a&lt;br&gt;protocol of double centrifugation of whole blood from each animal. After sterile skin preparation, full-thickness excisional&lt;br&gt;wounds (20 mm x 20 mm) were created on the back of each animal. The animals were randomly divided into three equal&lt;br&gt;groups of three sheep for each. In Group I, the wounds were treated with PRP, in Group II; wounds were treated with&lt;br&gt;Asiaticoside; in Group III, wounds were treated with saline solution. The different treatments were administered topically&lt;br&gt;every 3 days. Morphometric measurements of the contraction surface of the wounds and histopathological biopsies were&lt;br&gt;carried out at the 3rd, 7th, 14th, 21st, and 28th days of healing.&lt;br&gt;Results: The results of the morphometric data obtained revealed that it was significant differences recorded at the 7th and&lt;br&gt;14th day of healing in favor for animals of Group I. Semi-quantitative histopathological evaluation showed that PRP reduces&lt;br&gt;inflammation during 3 first days post-surgical and promotes epithelialization in 3 weeks of healing.&lt;br&gt;Conclusion: We concluded that topical administration of PRP obtained by double centrifugation protocol could potentially&lt;br&gt;improve the skin healing process in sheep.</style></abstract><issue><style face="normal" font="default" size="100%">2231-0916</style></issue></record></records></xml>