Abstract:

Aims: Non-alcoholic fatty liver disease is strongly linked to obesity and insulin resistance. The triglyceride-glucose index (TyG index) has been proposed as a reliable biomarker of insulin resistance. Our aims is to study the contribution of the TyG 
index as a marker in the association of non-alcoholic fatty liver disease, obesity and insulin resistance. Material and method:This was a cross-sectional study of obese women (age>18years,BMI≥29.9Kg/m2). Non-alcoholic hepatitis steatosis was confirmed by abdominal ultrasound. The viral origin of the liver disease was eliminated by microbiological test. A lipid profile was performed. The TyG index was calculated according to the formula Ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2. The relations between TyG index body
composition and lipid profile was measured. Results: 42 obese women participated in our work. Age=50.80±10.33 years. BMI=40.80±5.09 Kg/m2; weight=98.1±15.99 Kg. Fasting blood sugar was 1.18±0.34 g/L. Triglycerides were 1.37±0.47 g/L. Our study demonstrated that 83% (n= 35) have, in addition to nonalcoholic fatty liver disease, a high TyG index (4.75+/-0.25) in favour of insulin resistance. The TyG index is strongly linked to fasting glucose (rs=0.83) and fasting triglycerides (rs=0.78). A statistically significant link was found between the TyG index and age (τ = 0.21, p=0.04), the TyG index and total cholesterol (τ = 0.33, p=0.001). Conclusions: The TyG index is a topical biomarker. This clue is practical. It appears to have a place in the association, obesity, non-alcoholic fatty liver disease and insulin resistance.
Keywords: TyG index, insulin resistance, obesity, non-alcoholic fatty liver disease

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